A CMOS Hall-Effect Sensor for the Characterization and Detection of Magnetic Nanoparticles for Biomedical Applications

Author

Liu, Peng ; Skucha, K. ; Megens, M. ; Boser, Bernhard

Author_Institution

Dept. of Electr. Eng. & Comput. Sci., Univ. of California at Berkeley, Berkeley, CA, USA

Volume

47

Issue

10

fYear

2011

Firstpage

3449

Lastpage

3451

Abstract

A CMOS Hall-effect sensor chip designed for the characterization and detection of magnetic nanoparticles (MNPs) achieves over three orders of magnitude better temporal resolution than prior solutions based on superconducting quantum interference devices and fluxgate sensors. The sensor relies on wires embedded in the chip to generate a local magnetizing field that is switched OFF rapidly to observe the relaxation field of the MNPs. The CMOS sensor chip, with integrated high-speed readout electronics, occupies 6.25 mm². It can be easily integrated with microfluidics and is suitable for lab-on-a-chip and point-of-care applications.

Keywords

Hall effect; Hall effect devices; biomedical materials; biosensors; magnetic particles; magnetic relaxation; magnetic sensors; nanomedicine; nanoparticles; readout electronics; CMOS Hall-effect sensor chip; biomedical applications; fluxgate sensors; integrated high-speed readout electronics; lab-on-a-chip application; local magnetizing field; magnetic nanoparticle characterization; magnetic nanoparticle detection; microfluidics; point-of-care application; relaxation field; superconducting quantum interference devices; temporal resolution; Anisotropic magnetoresistance; CMOS integrated circuits; Magnetic moments; Magnetometers; Perpendicular magnetic anisotropy; Superconducting magnets; Biosensor; CMOS; Hall-effect devices; magnetic nanoparticles (MNPs); magnetic relaxation;

fLanguage

English

Journal_Title

Magnetics, IEEE Transactions on

Publisher

ieee

ISSN

0018-9464

Type

jour

DOI

10.1109/TMAG.2011.2158600

Filename

6028009