Title :
Efficient Molecular Imaging Techniques Using Optically Active Molecules
Author :
Giakos, G.C. ; Paturi, S. Atreya ; Valluru, K. ; Bathini, P. ; Adya, V. ; Sukumar, S. ; Ambadipudi, K. ; Mandadi, B. ; Becker, M. ; Athawale, S. ; Farajipour, P. ; Marotta, S. ; Sheffer, D. ; Livanos, George ; Zervakis, Michael
Author_Institution :
Dept. of Electr. & Comput. Eng., Univ. of Akron, Akron, OH, USA
Abstract :
Efficient imaging techniques aimed at the increasing of the image contrast of a structure, surrounded by a scattering medium, using optically active and high index of refraction molecules as molecular contrast agents, are presented. Specifically, an enhanced degree of linear polarization (DOLP) target detection and imaging is obtained by doping the surrounding medium with molecular contrast agents consisting of aqueous glucose, aqueous alcohol, and salt molecules, in conjunction with advanced polarimetric imaging techniques. The outcome of this paper opens new horizons in the areas of imaging, with emphasis on medical arena, industry, and detection technology.
Keywords :
biomedical optical imaging; polarimetry; refractive index; DOLP; advanced polarimetric imaging; aqueous alcohol; aqueous glucose; image contrast; linear polarization; molecular contrast agents; molecular imaging; optically active molecules; refractive index; salt molecules; target detection; Biomedical optical imaging; Optical imaging; Optical polarization; Optical refraction; Optical scattering; Optical sensors; Enhanced degree of linear polarization (DOLP); Stokes´ parameters imaging; enhanced DOLP image contrast resolution; high index of refraction molecules; molecular imaging using optically active molecules;
Journal_Title :
Instrumentation and Measurement, IEEE Transactions on
DOI :
10.1109/TIM.2010.2045538