Autonomic neural control of cerebral hemodynamics

Author

Mitsis, Georgios D. ; Zhang, Rong ; Levine, Benjamin D. ; Tzanalaridou, Efthalia ; Katritsis, Demosthenes G. ; Marmarelis, Vasilis Z.

Author_Institution

Univ. of Cyprus, Nicosia, Cyprus

Volume

28

Issue

6

fYear

2009

Firstpage

54

Lastpage

62

Abstract

The present article examines the role of autonomic neural control on both dynamic pressure autoregulation and CO₂ reactivity in the frequency range between 0.005 and 0.40 Hz by analyzing experimental data from healthy humans and using a nonlinear multivariate modeling approach. The data were obtained during control conditions and autonomic ganglionic blockade, induced by intravenous infusion of trimethaphan. This approach has been successfully used previously to describe cerebral hemodynamics during resting conditions and orthostatic stress.

Keywords

biocontrol; blood vessels; haemodynamics; neurophysiology; nonlinear dynamical systems; arterial blood pressure; autonomic ganglionic blockade; autonomic neural control; carbon dioxide reactivity; cerebral blood flow; cerebral hemodynamics; dynamic pressure autoregulation; end-tidal carbon dioxide; frequency 0.005 Hz to 0.40 Hz; nonlinear multivariate modeling; orthostatic stress conditions; resting condition; transcranial Doppler ultrasound; trimethaphan intravenous infusion; Arteries; Blood flow; Coherence; Fluctuations; Hemodynamics; Humans; Pressure measurement; Probes; Stress; Time measurement; Adult; Autonomic Nerve Block; Autonomic Nervous System; Blood Pressure; Carbon Dioxide; Cerebral Arteries; Cerebrovascular Circulation; Female; Heart Rate; Humans; Male; Models, Cardiovascular; Multivariate Analysis; Nonlinear Dynamics; Ultrasonography, Doppler, Transcranial;

fLanguage

English

Journal_Title

Engineering in Medicine and Biology Magazine, IEEE

Publisher

ieee

ISSN

0739-5175

Type

jour

DOI

10.1109/MEMB.2009.934908

Filename

5335720