Title :
Effect of cushing response on systemic arterial pressure
Author :
Ursino, Mauro ; Giannessi, Massimo ; Frapparelli, Marta ; Magosso, Elisa
Author_Institution :
Dipt. di Elettron., Inf. e Sist., Cesena, Italy
Abstract :
This work investigates the complex relationships between cerebrovascular dynamics, intracranial pressure (ICP), Cushing response, and short-term systemic regulation via an original mathematical model. The model has been used to analyze the effects of Cushing response on cardiovascular and cerebrovascular quantities during constant ICP elevation and during the occurrence of ICP plateau waves and to investigate the conditions leading to system instability with the formation of slow (0.05-0.1 Hz) arterial pressure waves. The model may be of value to assist clinicians in finding the balance between clinical benefits of Cushing response and its shortcomings.
Keywords :
blood vessels; brain; cardiovascular system; diseases; haemodynamics; neurophysiology; physiological models; Cushing response; ICP; cardiovascular quantities; cerebrovascular dynamics; intracranial pressure; neurosurgical patients; original mathematical model; short-term systemic regulation; slow arterial pressure waves; Baroreflex; Blood pressure; Cardiology; Dogs; Heart rate; Hypertension; Ischemic pain; Laboratories; Mathematical model; Neurosurgery; Algorithms; Blood Circulation; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Computer Simulation; Craniocerebral Trauma; Homeostasis; Humans; Intracranial Pressure; Models, Cardiovascular;
Journal_Title :
Engineering in Medicine and Biology Magazine, IEEE
DOI :
10.1109/MEMB.2009.934622
