DocumentCode :
1340560
Title :
Effect of Model Accuracy on the Result of Computed Current Densities in the Simulation of Transcranial Magnetic Stimulation
Author :
Golestanirad, Laleh ; Mattes, Michael ; Mosig, Juan R. ; Pollo, Claudio
Author_Institution :
Lab. of Electromagn. & Acoust., Ecole Polytech. Fed. de Lausanne (EPFL), Lausanne, Switzerland
Volume :
46
Issue :
12
fYear :
2010
Firstpage :
4046
Lastpage :
4051
Abstract :
In this paper, we study the effects of model complexity on the accuracy of the results in the computer simulation of transcranial magnetic stimulation (TMS). The method has been extensively used in the last decade as a noninvasive technique to excite neurons in the brain by inducing weak electric currents in the tissue and proved to be a very promising alternative for currently invasive treatments in Parkinson´s and Alzheimer´s diseases. A detailed 3-D model of a human head has been developed by combining individual patient-based brain images and the public domain Visible Human data consisting of brain white/gray matter, CSF, skull, and muscles. The finite-element method (low-frequency Ansoft Maxwell 3D package) is used to simulate the interaction of time-varying magnetic fields with brain tissues and to compute the densities of induced currents in different areas. Models with different levels of tissue separation have been developed and tested under the same condition to investigate the effects of model complexity on the distribution of fields and induced currents inside different tissues.
Keywords :
biological tissues; brain models; finite element analysis; neurophysiology; patient treatment; transcranial magnetic stimulation; Alzheimer diseases; CSF; Parkinson disease; brain; current density; finite element method; gray matter; muscles; skull; tissue separation; transcranial magnetic stimulation; white matter; Biological system modeling; Brain modeling; Computational modeling; Current density; Muscles; Solid modeling; Three dimensional displays; Anatomical head model; finite-element method; induced current density; patient-based model; transcranial magnetic stimulation;
fLanguage :
English
Journal_Title :
Magnetics, IEEE Transactions on
Publisher :
ieee
ISSN :
0018-9464
Type :
jour
DOI :
10.1109/TMAG.2010.2082556
Filename :
5593219
Link To Document :
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