A system for tracking changes in the mid-latency evoked potential during anesthesia

Describes a method to measure changes in the mid-latency auditory evoked potential (MLAEP) during anesthesia. It is claimed that the position of the Nb-trough of the MLAEP indicates the level of consciousness. The component shows graded changes corresponding to the dose of anesthetic and it exhibits stable reproducible properties between different subjects. The authors propose a system that reduces the disturbances in an averaged MLAEP using fewer realizations than in the standard averaging procedure. The resulting smoothing error is reduced if the number of stimulus is decreased. Unfortunately, the variance of the waveform estimate is, thereby, increased. An improved method must be used in order to estimate the Nb-trough within a prescribed time interval of one minute. The procedure is based on inherent properties of the MLAEP and the noise. A simulation and examples of the performance on real data recorded during surgery are shown.