• DocumentCode
    1373514
  • Title

    Graph Formations of Partial-Order Multiple-Sequence Alignments Using Nanoscale, Microscale, and Multiscale Reconfigurable Meshes

  • Author

    Eshaghian-Wilner, M.M. ; Ling Lau ; Navab, S. ; Shen, Dayong

  • Author_Institution
    Electr. Eng. Dept., Univ. of California, Los Angeles, CA, USA
  • Volume
    8
  • Issue
    3
  • fYear
    2009
  • Firstpage
    201
  • Lastpage
    209
  • Abstract
    In this paper, we show how to form partial-order multiple-sequence alignment graphs on two types of reconfigurable mesh architectures. The first reconfigurable mesh is a standard microscale that uses electrical interconnects, while the second type of reconfigurable mesh can be implemented at a nanoscale level and employs spin waves for interconnectivity. We consider graph formations for two cases. In one case, the number of distinct variables in the data sequences is constant. In the other case, it can be as much as O(N). We show that given O(N) aligned sequences of length L, we can combine the sequences to form a graph in O(1) time, using either architecture if there is a constant number of distinct variables in the sequence. Otherwise, it will take O(1) time if we use the spin-wave model and O(N) time if we use the standard very large scale integration version.
  • Keywords
    bioinformatics; coprocessors; graph theory; molecular biophysics; parallel algorithms; reconfigurable architectures; electrical interconnects; interconnectivity; microscale reconfigurable mesh; multiscale reconfigurable mesh; nanoscale reconfigurable mesh; partial order multiple sequence alignment graph formation; reconfigurable mesh architecture; spin waves; spin-wave model; Bioinformatics; Biological system modeling; Computational biology; Computer architecture; DNA; Genomics; Hardware; Humans; Nanobioscience; Sequences; Parallel computing; partial-order multiple sequence alignment; reconfigurable mesh; spin wave; Algorithms; Base Sequence; DNA; Molecular Sequence Data; Nanotechnology; Numerical Analysis, Computer-Assisted; Sequence Alignment; Sequence Analysis, DNA;
  • fLanguage
    English
  • Journal_Title
    NanoBioscience, IEEE Transactions on
  • Publisher
    ieee
  • ISSN
    1536-1241
  • Type

    jour

  • DOI
    10.1109/TNB.2009.2029230
  • Filename
    5371780