Title :
Latex piezoelectric immunoassay: analysis of C-reactive protein in human serum
Author :
Kurosawa, Shigeru ; Aizawa, Hidenobu ; Yoshimoto, Minoru
Author_Institution :
Nat. Inst. of Mater. & Chem. Res., Tsukuba, Japan
Abstract :
We constructed an integrated immunosensor system to combine a quartz crystal microbalance with the agglutination reaction of immunized latex beads. C-reactive protein (CRP) induced an immunoreaction due to the latex bends with anti-CRP antibody. We succeeded in determining the concentration of CRP necessary in human serum for disease diagnosis using a CRP Sensor I.
Keywords :
biosensors; crystal resonators; microbalances; patient diagnosis; proteins; C-reactive protein; CRP Sensor I; agglutination reaction; anti-CRP antibody; clinical analysis; disease diagnosis; human blood serum; immunoreaction; integrated immunosensor; latex piezoelectric immunoassay; pneumonia; quartz crystal microbalance; Blood; Chemicals; Crystalline materials; Humans; Immune system; Lungs; Proteins; Radio frequency; Senior citizens; Testing;
Journal_Title :
Ultrasonics, Ferroelectrics, and Frequency Control, IEEE Transactions on
