A mathematical model for the assessment of hemodynamic parameters using quantitative contrast echocardiography

Author

Chen, Xucai ; Schwarz, Karl Q. ; Phillips, Daniel ; Steinmetz, Sherry D. ; Schlief, Reinhard

Author_Institution

Dept. of Med., Rochester Univ., NY, USA

Volume

45

Issue

6

fYear

1998

fDate

6/1/1998 12:00:00 AM

Firstpage

754

Lastpage

765

Abstract

A mathematical model for the assessment of hemodynamic parameters using quantitative echocardiography is presented. The method involves the intravenous injection of an ultrasonic echo contrast agent. The relative enhancement of the backscattered ultrasound intensity is measured as a function of time (the time-intensity curve). From this measurement, the volume flow rate (cardiac output) and the mixing volume are calculated. Relevant acoustic properties of the ultrasound contrast agent are discussed. An in vitro experiment is performed to corroborate the theory presented.

Keywords

backscatter; echocardiography; haemodynamics; physiological models; acoustic properties; backscattered ultrasound intensity relative enhancement; cardiac output; hemodynamic parameters assessment; in vitro experiment; intravenous injection; mathematical model; medical diagnostic imaging; mixing volume; quantitative contrast echocardiography; time-intensity curve; ultrasonic echo contrast agent; ultrasound contrast agent; volume flow rate; Acoustic measurements; Echocardiography; Fluid flow measurement; Hemodynamics; In vitro; Mathematical model; Time measurement; Ultrasonic imaging; Ultrasonic variables measurement; Volume measurement; Calibration; Contrast Media; Echocardiography; Hemodynamics; Humans; Image Enhancement; Models, Cardiovascular; Nonlinear Dynamics; Phantoms, Imaging; Reproducibility of Results;

fLanguage

English

Journal_Title

Biomedical Engineering, IEEE Transactions on

Publisher

ieee

ISSN

0018-9294

Type

jour

DOI

10.1109/10.678610

Filename

678610