Microrobotic platform for mechanical stimulation of swimming microorganism on a chip

We propose a microrobotic platform that stimulates swimming microorganisms in a microfluidic chip with high speed and accuracy. The developed platform comprises (1) high-speed microrobots that can generate a millinewton-level driving force, micrometer-level positioning accuracy, and a millimeter per second level drive speed through the actuation of motorized stages with permanent magnets and (2) high-speed online vision sensor capable of capturing images on the order of 1000 frames per second. The specific design and architecture of the proposed platform are also presented. The proposed platform stimulates and observes swimming microorganisms in a microfluidic chip through a mechanical approach. This platform provides on-chip investigation with high functionality that has been difficult to achieve with previous approaches and contributes towards the discovery of previously unknown functions of swimming microorganisms in the bioscience fields.