DocumentCode
1389141
Title
Microchannel plate detectors for 14C autoradiography
Author
Lees, J.E. ; Fraser, G.W. ; Carthew, P.
Author_Institution
Dept. of Phys. & Astron., Leicester Univ., UK
Volume
45
Issue
3
fYear
1998
fDate
6/1/1998 12:00:00 AM
Firstpage
1288
Lastpage
1292
Abstract
We describe a new type of detector for digital autoradiography which combines high sensitivity, useful detecting area (93×93 mm) and good spatial resolution (<100 μm). This instrument is suitable, inter alia, for imaging beta-emitting whole body thin tissue slices. Measured detector sensitivity and linearity derived from images of a 14C Standard are presented. We also describe results from (i) a 14C labelled rat whole body slice showing selective radiopharmaceutical uptake in clearly identifiable organs and (ii) 14C-Tamoxifen doped semi-thin tissue sections of rat womb and liver
Keywords
beta-ray detection; biomedical equipment; microchannel plates; radioisotope imaging; 93 mm; 14C autoradiography; 14C labelled rat whole body slice; 14C-Tamoxifen doped semi-thin tissue section; beta-emitting whole body thin tissue slices; detector sensitivity; digital autoradiography; high sensitivity; linearity; microchannel plate detectors; rat liver; rat womb; selective radiopharmaceutical uptake; spatial resolution; useful detecting area; Anodes; Background noise; Bars; Gamma ray detection; Gamma ray detectors; Glass; Image resolution; Microchannel; Noise level; Spatial resolution;
fLanguage
English
Journal_Title
Nuclear Science, IEEE Transactions on
Publisher
ieee
ISSN
0018-9499
Type
jour
DOI
10.1109/23.682018
Filename
682018
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