Automatic registration of postmortem brain slices to MRI reference volume

Author

Kim, T.-S. ; Singh, M. ; Sungkara, W. ; Zarow, C. ; Chui, H.

Author_Institution

Dept. of Radiol. & Biomed. Eng., Univ. of Southern California, CA, USA

Volume

47

Issue

4

fYear

2000

fDate

8/1/2000 12:00:00 AM

Firstpage

1607

Lastpage

1613

Abstract

A new strategy to register each slice of the postmortem brain to anatomically corresponding in-vivo MRI slices is presented. The approach relies on a recursive reslicing of the FVIRI volume using non-linear polynomial transformations. Simulation studies to validate the approach and results using real data are presented. The results suggest the feasibility and practicability of second- and third-order polynomials to register postmortem images on a slice-by-slice basis to corresponding MRI sections. Using this method, it is possible to investigate the pathology of a disease through routinely acquired MRIs and postmortem brain images

Keywords

biomedical MRI; brain; image registration; medical image processing; polynomials; MRI reference volume; anatomically corresponding in-vivo MRI slices; automatic registration; disease pathology investigation; magnetic resonance imaging; medical diagnostic imaging; nonlinear polynomial transformations; postmortem brain slices; second-order polynomials; simulation studies; slice-by-slice basis; third-order polynomials; Alzheimer´s disease; Biomedical engineering; Brain; Image reconstruction; Image registration; Magnetic resonance imaging; Nonlinear distortion; Pathology; Polynomials; Radiology;

fLanguage

English

Journal_Title

Nuclear Science, IEEE Transactions on

Publisher

ieee

ISSN

0018-9499

Type

jour

DOI

10.1109/23.873023

Filename

873023