DocumentCode :
139238
Title :
Using functional MRI alone for localization in focal epilepsy
Author :
Zhang, Clara H. ; Yunfeng Lu ; Brinkmann, Benjamin ; Welker, Kirk ; Worrell, Gregory ; Bin He
Author_Institution :
Dept. of Biomed. Eng., Univ. of Minnesota, Minneapolis, MN, USA
fYear :
2014
fDate :
26-30 Aug. 2014
Firstpage :
730
Lastpage :
733
Abstract :
In the present study, we developed a method for the purpose of localizing epilepsy related hemodynamic foci for patients suffering intractable focal epilepsy using resting state fMRI alone. We studied two groups of subjects: five patients with intractable focal epilepsy, and ten healthy volunteers performing motor tasks. Spatial independent component analysis (ICA) was performed on the fMRI alone data and a set of independent component (IC) selection criteria was developed to identify epilepsy related ICs. The method was then evaluated in the healthy group with motor tasks. In all five surgery patients, there was at least one identified IC concordant with surgical resection. In the motor task study of healthy subjects, our method revealed components with concordant spatial and temporal features as expected from the unilateral motor tasks. These results suggest the lateralization and localization value of fMRI alone in presurgical evaluation for patients with intractable unilateral focal epilepsy. The proposed method is noninvasive in nature and easy to implement. It has the potential to be incorporated in current presurgical workup for the diagnosis of intractable focal epilepsy patients.
Keywords :
biomedical MRI; haemodynamics; independent component analysis; medical disorders; neurophysiology; epilepsy related hemodynamic foci; fMRI; focal epilepsy localization; functional MRI; intractable focal epilepsy; spatial independent component analysis; unilateral motor tasks; Electroencephalography; Electronic mail; Epilepsy; Hemodynamics; Magnetic resonance imaging; Manganese; Surgery;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE
Conference_Location :
Chicago, IL
ISSN :
1557-170X
Type :
conf
DOI :
10.1109/EMBC.2014.6943694
Filename :
6943694
Link To Document :
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