DocumentCode :
139245
Title :
Diffusion tensor MRI phantom exhibits anomalous diffusion
Author :
Ye, Allen Q. ; Hubbard Cristinacce, Penny L. ; Feng-Lei Zhou ; Ziying Yin ; Parker, Geoff J. M. ; Magin, Richard L.
Author_Institution :
Univ. of Illinois at Chicago, Chicago, IL, USA
fYear :
2014
fDate :
26-30 Aug. 2014
Firstpage :
746
Lastpage :
749
Abstract :
This paper reports diffusion weighted MRI measurements of cyclohexane in a novel diffusion tensor MRI phantom composed of hollow coaxial electrospun fibers (average diameter 10.2 μm). Recent studies of the phantom demonstrated its potential as a calibration standard at low b values (less than 1000 s/mm<;sup>2<;/sup>) for mean diffusivity and fractional anisotropy. In this paper, we extend the characterization of cyclohexane diffusion in this heterogeneous, anisotropic material to high b values (up to 5000 s/mm<;sup>2<;/sup>), where the apparent diffusive motion of the cyclohexane exhibits anomalous behavior (i.e., the molecular mean squared displacement increases with time raised to the fractional power 2α/β). Diffusion tensor MRI was performed at 9.4 T using an Agilent imaging scanner and the data fit to a fractional order Mittag-Leffler (generalized exponential) decay model. Diffusion along the fibers was found to be Gaussian (2α/β=l), while diffusion across the fibers was sub-diffusive (2α/β<;l). Fiber tract reconstruction of the data was consistent with scanning electron micrograph images of the material. These studies suggest that this phantom material may be used to calibrate MR systems in both the normal (Gaussian) and anomalous diffusion regimes.
Keywords :
Gaussian processes; anisotropic media; biodiffusion; biomedical MRI; electrospinning; image reconstruction; medical image processing; phantoms; Agilent imaging scanner; Gaussian diffusion; MR systems; anisotropic material; anomalous behavior; anomalous diffusion regime; apparent diffusive motion; calibration standard; cyclohexane diffusion characterization; diffusion tensor MRI phantom; diffusion weighted MRI measurements; fiber tract reconstruction; fractional anisotropy; fractional order Mittag-Leffler decay model; heterogeneous material; hollow coaxial electrospun fibers; magnetic flux density 9.2 T; mean diffusivity; normal diffusion regime; phantom material; scanning electron micrograph images; size 10.2 mum; Biological system modeling; Brain modeling; Diffusion tensor imaging; Phantoms; Standards;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE
Conference_Location :
Chicago, IL
ISSN :
1557-170X
Type :
conf
DOI :
10.1109/EMBC.2014.6943698
Filename :
6943698
Link To Document :
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