Title :
Parallel computing strategies for determining viral capsid structure by cryoelectron microscopy
Author :
Lanczycki, Chfustopher J. ; Johnson, Cawin A. ; Trus, Benes L. ; Conway, James F. ; Steven, Alasdair C. ; Martino, Robert L.
Author_Institution :
US Nat. Inst. of Health, USA
Abstract :
To calculate a full 3D structural model of a virus capsid, researchers analyzed cryoelectron micrographs that contain many randomly oriented images of the views. The authors use parallel computing techniques to improve the performance of the computational algorithms that determine each particle´s orientation and generate the 3D model. This enhanced computational performance allows analysis of many more particles and a more precise determination of their orientations, letting researchers study important details of virus capsids at higher resolutions
Keywords :
biology computing; biothermics; microscopy; parallel algorithms; 3D model; computational algorithms; cryoelectron micrographs; cryoelectron microscopy; enhanced computational performance; full 3D structural model; parallel computing strategies; parallel computing techniques; randomly oriented images; viral capsid structure; virus capsid; Concurrent computing; Crystallography; Electron microscopy; Image analysis; Image reconstruction; Image resolution; Parallel processing; Pathogens; Proteins; Viruses (medical);
Journal_Title :
Computational Science & Engineering, IEEE
