DocumentCode :
139760
Title :
Chronic sensory-motor activity in behaving animals using regenerative multi-electrode interfaces
Author :
Desai, Vijay H. ; Anand, Sruthy ; Tran, M. ; Kanneganti, A. ; Vasudevan, S. ; Seifert, J.L. ; Cheng, James ; Keefer, E.W. ; Romero-Ortega, M.I.
Author_Institution :
Univ. of Texas at Arlington, Arlington, TX, USA
fYear :
2014
fDate :
26-30 Aug. 2014
Firstpage :
1973
Lastpage :
1976
Abstract :
Regenerative peripheral nerve interfaces have been proposed as viable alternatives for the natural control and feel of robotic prosthetic limbs. We have developed a Regenerative Multi-electrode Interface (REMI) that guides re-growing axons through an electrode array deployed in the lumen of a nerve guide. While acute studies have shown the use of the REMI in the rat sciatic nerve, the quality of chronic signal recording has not been reported. Here we show that implantation of this interface in the sciatic nerve is stable with high quality recordings up to 120 days and failures mainly attributable to abiotic factors related to pedestal detachment and wire breakage. We further tested the interfacing of REMI with fascicles of the sciatic nerve that primarily innervate muscles (tibial) and skin (sural). When implanted into the tibial nerve, bursting activity was observed synchronous to stepping. However, implantation of REMI into the sural nerve failed due to its small size. While fascicles smaller than 300 μm are a challenge for regenerative interfacing, we show that a modified REMI can be used in an insertion mode to record sensory signals from skin. In summary, the REMI represents an effective tool for recording firing patterns of specific axon types during voluntary movement, which may be used to improve the motor control and sensory feedback in closed loop control systems for robotic prosthesis.
Keywords :
biomedical electrodes; closed loop systems; electromyography; medical signal processing; microelectrodes; neurophysiology; skin; abiotic factors; axon regrowing; behaving animals; bursting activity; chronic sensory-motor activity; chronic signal recording quality; closed loop control systems; electrode array; electromyography; high-quality recordings; lumen; motor control; natural control; nerve guide; pedestal detachment; primarily innervate muscles; rat sciatic nerve; regenerative interfacing; regenerative multielectrode interfaces; robotic prosthesis; sensory feedback; skin; sural nerve; voluntary movement; wire breakage; Animals; Arrays; Connectors; Electrodes; Nerve fibers; Robot sensing systems; Signal to noise ratio;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE
Conference_Location :
Chicago, IL
ISSN :
1557-170X
Type :
conf
DOI :
10.1109/EMBC.2014.6944000
Filename :
6944000
Link To Document :
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