Title :
Functional validation of an implantable medical dosing device by MRI at 3T
Author :
Anderson, J.R. ; Ferrati, Silvia ; Karmonik, Chistof ; Grattoni, Alessandro
Author_Institution :
MR Core Facilites, Houston Methodist Res. Inst., Houston, TX, USA
Abstract :
Sustained release of a small molecule from a prototype implantable drug delivery device was monitored via MRI in an ex vivo tissue phantom over a period of two days. T1 mapping was used as a method to quantify analyte concentration. Continuous, controlled release was observed. The MRI methodology was thus found to be appropriate for device validation and quality assurance/control.
Keywords :
biochemistry; biodiffusion; biological tissues; biomedical MRI; chemical analysis; drug delivery systems; drugs; patient monitoring; phantoms; prosthetics; prototypes; quality assurance; quality control; MRI; T1 mapping; analyte concentration quantification; continuous controlled release; ex vivo tissue phantom; implantable drug delivery device; implantable medical dosing device; magnetic flux density 3 T; medical dosing device functional validation; prototype; quality assurance; quality control; small molecule release monitoring; sustained release monitoring; time 2 day; Containers; Drug delivery; Implants; Magnetic resonance imaging; Phantoms;
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE
Conference_Location :
Chicago, IL
DOI :
10.1109/EMBC.2014.6944091
