Title :
Impact of multivariate granger causality analyses with embedded dimension reduction on network modules
Author :
Schmidt, Christoph ; Pester, Britta ; Nagarajan, Mahesh ; Witte, Herbert ; Leistritz, Lutz ; Wismueller, Axel
Author_Institution :
Bernstein Group for Comput. Neurosci. Jena, Jena Univ. Hosp., Jena, Germany
Abstract :
High dimensional functional MRI data in combination with a low temporal resolution imposes computational limits on classical Granger Causality analyses with respect to a large-scale representations of functional interactions in the brain. To overcome these limitations and exploit information inherent in resulting brain connectivity networks at the large scale, we propose a multivariate Granger Causality approach with embedded dimension reduction. Using this approach, we computed binary connectivity networks from resting state fMRI images and analyzed them with respect to network module structure, which might be linked to distinct brain regions with an increased density of particular interaction patterns as compared to inter-module regions. As a proof of concept, we show that the modular structure of these large-scale connectivity networks can be recovered. These results are promising since further analysis of large-scale brain network partitions into modules might prove valuable for understanding and tracing changes in brain connectivity at a more detailed resolution level than before.
Keywords :
biomedical MRI; brain; image resolution; medical image processing; binary connectivity networks; brain connectivity networks; embedded dimension reduction; high dimensional functional MRI data; large-scale brain network partition; large-scale connectivity networks; low temporal resolution; multivariate Granger causality analyses; network module structure; resting state fMRI images; Communities; Educational institutions; High definition video; Indexes; Magnetic resonance imaging; Optical wavelength conversion; Time series analysis;
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE
Conference_Location :
Chicago, IL
DOI :
10.1109/EMBC.2014.6944204