Title :
Methods for Optimal Intervention in Gene Regulatory Networks [Applications Corner]
Author :
Bouaynaya, Nidhal ; Shterenberg, Roman ; Schonfeld, Dan
Author_Institution :
Syst. Eng. Dept., Univ. of Arkansas at Little Rock, Little Rock, AR, USA
Abstract :
In this column, we review recent results in gene regulatory network modeling and discuss various control mechanisms used to modify their cellular dynamics. We subsequently describe a new intervention strategy based on optimal perturbations, which force the network to converge to a desired steady-state distribution of gene regulation.
Keywords :
cellular biophysics; genetics; cellular dynamics; control mechanism; gene regulation; gene regulatory network modeling; steady-state distribution; Biochemistry; Biological cells; Cancer; Cells (biology); Diseases; Feedback; Genetic communication; Genetics;
Journal_Title :
Signal Processing Magazine, IEEE
DOI :
10.1109/MSP.2011.943128
