A multi-scale feedback control system model for wound healing electrical activity: Therapeutic device/protocol implications

Regulation, growth and healing in biological systems involve many interconnected and interdependent processes that include chemical and electrical mechanisms of action. Unfortunately, the significant contributions that electrical events provide are often overlooked; resulting in a poor transfer of knowledge from science, to engineering and finally to therapy. Wound site electrical processes can influence cell migration, fluid transport, cellular signaling events, gene expression, cell differentiation and cell proliferation; affecting both form and function at the cell, tissue and organ levels. Wound healing, and its interrelationships with transport, regeneration, and growth, cannot be understood or therapeutically assisted unless both chemical and electrical activities associated with the healing process are addressed.