Osteoinductive Calcium Phosphate clay nanoparticle bone cements (CPCs) with enhanced mechanical properties

Author

Jammalamadaka, Udayabhanu ; Tappa, Karthik ; Mills, D.

fYear

2014

fDate

26-30 Aug. 2014

Firstpage

3917

Lastpage

3920

Abstract

Calcium Phosphate Cements (CPCs) with osteoconductive properties are limited in their applications because of their poor mechanical properties. This study investigated the additive effect of Dexamethasone-doped Halloysite Nanotubes (HNTs on the mechanical properties of CPCs. HNTs are nanosized tubes with alumino-silicate composition. Physico-chemical properties, cytocompatability and cellular functionality of the nanocomposites were assayed. Results suggest that these nanoenhanced composites have a huge potential to broaden the applications of CPCs.

Keywords

alumina; bioceramics; bone; calcium compounds; cellular biophysics; clay; mechanical properties; nanocomposites; nanomedicine; nanoparticles; nanotubes; silicon compounds; tissue engineering; Al₂O₃-SiO₂; alumino-silicate composition; cellular functionality; cytocompatability; dexamethasone-doped halloysite nanotubes; mechanical property enhancement; nanocomposite enhancement; nanoparticle bone cements; osteoinductive calcium phosphate clay; physico-chemical properties; Bones; Calcium; Chemicals; Liquids; Mechanical factors; Nanotubes; Surface topography;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE

Conference_Location

Chicago, IL

ISSN

1557-170X

Type

conf

DOI

10.1109/EMBC.2014.6944480

Filename

6944480