Interaction between microspheres of collagen/biphasic calcium phosphate and mesenchymal stem cells

Collagen has been widely used as biomaterials for its excellent biocompatibility and the potential to guide tissue regeneration. Based on the inducing regeneration concept, collagen/biphasic calcium phosphate microspheres (BCP) were prepared by utilising emulsion polymerisation and the intrinsic self-assembly of collagen. The bioactivity of the micro collagen/BCP composites was preliminarily evaluated by in vitro co-culture with mesenchymal stem cells (MSCs) and the results indicated that the composites can provide an appropriate environment for the proliferation and osteogenic differentiation of MSCs and have a potential clinical application in the bone tissue engineering field.