Title :
Tapered metal microneedles fabricated by the hybrid process of mechanical dicing and electrochemical corrosion for drug delivery
Author :
Xiao-Xiao Yan ; Jing-Quan Liu ; Shui-Dong Jiang ; Bin Yang ; Chun-Sheng Yang
Author_Institution :
Nat. Key Lab. of Sci. & Technol. on Nano/Micro Fabrication, Shanghai Jiao Tong Univ., Shanghai, China
fDate :
12/1/2012 12:00:00 AM
Abstract :
Metal microneedles are fabricated by the process of cutting and electrochemical corrosion. The fabricated microneedles are 400 m in length, 700 m in space and have sharp tapered tips. In a force test, these microneedles could penetrate an artificial skin and a rat s skin well and safely. In a vitro transdermal drug delivery test, the amount of the permeated flux of calcein and of the bovine serum albumin through the treated rat skin increased by 35 and six times than that on the intact skin, respectively.
Keywords :
corrosion; cutting; drug delivery systems; drugs; electrochemistry; microfabrication; molecular biophysics; needles; proteins; skin; artificial skin; bovine serum albumin; calcein; cutting; electrochemical corrosion; hybrid process; intact skin; mechanical dicing; permeated flux; rat skin; sharp tapered tips; size 400 mum; size 700 mum; tapered metal microneedles; vitro transdermal drug delivery testing;
Journal_Title :
Micro & Nano Letters, IET
DOI :
10.1049/mnl.2012.0633
