DocumentCode :
140392
Title :
The implementation of acoustic angiography for microvascular and angiogenesis imaging
Author :
Dayton, Paul A. ; Gessner, Ryan C. ; Phillips, Linsey ; Shelton, Sarah E. ; Heath Martin, K. ; Lee, Minhung ; Foster, F. Stuart
Author_Institution :
Joint Dept. of Biomed. Eng., NC State Univ., Raleigh, NC, USA
fYear :
2014
fDate :
26-30 Aug. 2014
Firstpage :
4283
Lastpage :
4285
Abstract :
Recently, it has been demonstrated that through the use of contrast agents and multi-frequency transducer technology, high resolution and high signal to noise ultrasound images can be obtained which illustrate microvascular structure in unprecedented detail for an ultrasound modality. The enabling technology is ultrasound transducers which are fabricated with elements which can excite microbubble contrast agents near resonance and detect their broadband harmonics at a much higher bandwidth (several times the fundamental frequency). The resulting images contain very little background from tissue scattering and thus provide high contrast, and can have a resolution on the order of 130 microns with an appropriate high frequency receiving element. Because microbubbles are strictly an intravascular agent, this approach enables visualization of microvascular morphology with unique clarity, providing insight into angiogenesis associated with tumor development.
Keywords :
biomedical transducers; biomedical ultrasonics; blood vessels; bubbles; image resolution; tumours; ultrasonic transducers; acoustic angiography implementation; angiogenesis imaging; bandwidth; broadband harmonic detection; fundamental frequency; high frequency receiving element; image contrast; intravascular agent; microbubble contrast agent excitation; microvascular imaging; microvascular morphology visualization; microvascular structure; multifrequency transducer technology; tissue scattering; tumor development; ultrasound image resolution; ultrasound image signal to noise; ultrasound modality; ultrasound transducer elements; ultrasound transducer fabrication; Acoustics; Angiography; Image resolution; Transducers; Tumors; Ultrasonic imaging;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE
Conference_Location :
Chicago, IL
ISSN :
1557-170X
Type :
conf
DOI :
10.1109/EMBC.2014.6944571
Filename :
6944571
Link To Document :
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