Optical Clearing for OCT Image Enhancement and In-Depth Monitoring of Molecular Diffusion

Author

Larin, Kirill V. ; Ghosn, M.G. ; Bashkatov, A.N. ; Genina, E.A. ; Trunina, Natalia A. ; Tuchin, Valery V.

Author_Institution

Univ. of Houston, Houston, TX, USA

Volume

18

Issue

3

fYear

2012

Firstpage

1244

Lastpage

1259

Abstract

In this paper, we overview the basic principles, recent results, advantages, limitations, and future of the optical clearing method in application to many fields of biology and medicine. We also discuss the possibility of noninvasive assessment of molecular diffusion in tissues using the optical coherence tomography technique. Issues of safety and toxicity of application of different endogenous and exogenous molecules to tissues are outlined.

Keywords

biodiffusion; biological tissues; biomedical optical imaging; molecular biophysics; optical tomography; OCT image enhancement; endogenous molecules; exogenous molecules; in depth molecular diffusion monitoring; optical clearing agent safety; optical clearing agent toxicity; optical clearing method; optical coherence tomography; tissue molecular diffusion noninvasive assessment; Biomedical optical imaging; Blood; Optical imaging; Optical refraction; Optical scattering; Refractive index; Molecular diffusion; optical clearing; optical coherence tomography;

fLanguage

English

Journal_Title

Selected Topics in Quantum Electronics, IEEE Journal of

Publisher

ieee

ISSN

1077-260X

Type

jour

DOI

10.1109/JSTQE.2011.2181991

Filename

6112786