Title :
Magnetically Labeled GMR Biosensor With a Single Immobilized Ferrimagnetic Particle Agent for the Detection of Extremely Low Concentration of Biomolecules
Author :
Zhang, Ping ; Thiyagarajah, Naganivetha ; Bae, Seongtae
Author_Institution :
Dept. of Electr. & Comput. Eng., Nat. Univ. of Singapore, Singapore, Singapore
Abstract :
It was numerically and experimentally demonstrated that “one giant magnetoresistance (GMR) biosensor + single ferrimagnetic nanoparticle or micro particle sensor agent” architecture is more technically suitable for the detection of extremely low concentration of biomolecules than the “one GMR biosensor + single superparamagnetic nanoparticle sensor agent” architecture. The large remnant magnetization of a single immobilized ferrimagnetic nano or micro particle sensor agent that allows for, producing a sufficiently large stray magnetic field, maintaining negligibly small variation of interaction factor (IF) formed between the agent and the free layer (sensing layer) of the GMR biosensor, and a larger “effective sensing area” directly corresponding to a practically larger optimized sensor size, were found to be the main physical reasons for the technical promises.
Keywords :
biosensors; ferrimagnetism; giant magnetoresistance; microsensors; molecular biophysics; nanosensors; particle detectors; biomolecules; giant magnetoresistance biosensor; interaction factor; magnetic field; magnetically labeled GMR biosensor; microparticle sensor agent architecture; single ferrimagnetic nanoparticle architecture; single immobilized ferrimagnetic mciroparticle sensor; single immobilized ferrimagnetic nanoparticle sensor; single immobilized ferrimagnetic particle agent; single superparamagnetic nanoparticle sensor agent architecture; Biosensors; Frequency modulation; Magnetic fields; Magnetic sensors; Magnetization; Molecular biophysics; Extremely low concentration of biomolecules; ferrimagnetic particle agent; magnetically labeled giant magnetoresistance (GMR) biosensor; superparamagnetic nanoparticle agent;
Journal_Title :
Sensors Journal, IEEE
DOI :
10.1109/JSEN.2010.2102349