DocumentCode :
141447
Title :
Model based non-invasive estimation of PV loop from echocardiography
Author :
Itu, Lucian ; Sharma, Parmanand ; Georgescu, Bogdan ; Kamen, Ali ; Suciu, Constantin ; Comaniciu, Dorin
Author_Institution :
Siemens Corp. Res., Siemens SRL, Brasov, Romania
fYear :
2014
fDate :
26-30 Aug. 2014
Firstpage :
6774
Lastpage :
6777
Abstract :
We introduce a model-based approach for the non-invasive estimation of patient specific, left ventricular PV loops. A lumped parameter circulation model is used, composed of the pulmonary venous circulation, left atrium, left ventricle and the systemic circulation. A fully automated parameter estimation framework is introduced for model personalization, composed of two sequential steps: first, a series of parameters are computed directly, and, next, a fully automatic optimization-based calibration method is employed to iteratively estimate the values of the remaining parameters. The proposed methodology is first evaluated for three healthy volunteers: a perfect agreement is obtained between the computed quantities and the clinical measurements. Additionally, for an initial validation of the methodology, we computed the PV loop for a patient with mild aortic valve regurgitation and compared the results against the invasively determined quantities: there is a close agreement between the time-varying LV and aortic pressures, time-varying LV volumes, and PV loops.
Keywords :
blood pressure measurement; blood vessels; cardiovascular system; echocardiography; optimisation; parameter estimation; physiological models; aortic pressures; clinical measurements; echocardiography; fully automated parameter estimation framework; fully automatic optimization-based calibration method; left atrium; left ventricle; left ventricular PV loops; lumped parameter circulation model; mild aortic valve regurgitation; model based noninvasive estimation; model personalization; parameter series; patient specific PV loops; pulmonary venous circulation; systemic circulation; time-varying LV volumes; Computational modeling; Echocardiography; Estimation; Linear programming; Mathematical model; Parameter estimation; Valves;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE
Conference_Location :
Chicago, IL
ISSN :
1557-170X
Type :
conf
DOI :
10.1109/EMBC.2014.6945183
Filename :
6945183
Link To Document :
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