A 3-D Microdosimetric Study on Blood Cells: A Permittivity Model of Cell Membrane and Stochastic Electromagnetic Analysis

Author

Merla, Caterina ; Liberti, Micaela ; Apollonio, Francesca ; Nervi, Clara ; D´Inzeo, G.

Author_Institution

Italian Inter-Univ. Centre for the Study of Electromagn. Fields & BioSystems (ICEmB), Univ. of Rome "La Sapienza", Rome, Italy

Volume

58

Issue

3

fYear

2010

fDate

3/1/2010 12:00:00 AM

Firstpage

691

Lastpage

698

Abstract

This paper describes a microdosimetric study on erythrocytes in two parts: an assessment of the membrane dielectric model from permittivity measurements of erythrocyte solutions and its uncertainty, and a quasi-static electromagnetic (EM) analysis solving the Laplace equation, both analytically and numerically. To evaluate the role of the estimated uncertainty, a stochastic EM solution has been conducted; our results highlight the fundamental role of the dielectric modeling on the reliability of electric field values in the cell membrane. Numerical data, from 3-D cell models, confirm the dependence of the electric field distribution on the extra-cellular field polarization.

Keywords

Laplace equations; bioelectric phenomena; biomembranes; blood; cellular biophysics; dosimetry; permittivity; stochastic processes; 3D cell models; 3D microdosimetric study; Laplace equation; blood cells; cell membrane; dielectric modeling; electric field distribution; electric field values; erythrocytes; extracellular field polarization; membrane dielectric model; permittivity model; quasistatic electromagnetic analysis; stochastic electromagnetic analysis; Dielectric model; erythrocyte; microdosimetry; quasi-static solution;

fLanguage

English

Journal_Title

Microwave Theory and Techniques, IEEE Transactions on

Publisher

ieee

ISSN

0018-9480

Type

jour

DOI

10.1109/TMTT.2010.2040338

Filename

5418824