DocumentCode :
1425146
Title :
Methodologies for Developing Surface-Enhanced Raman Scattering (SERS) Substrates for Detection of Chemical and Biological Molecules
Author :
Dhawan, Anuj ; Du, Yan ; Yan, Fei ; Gerhold, Michael D. ; Misra, Veena ; Vo-Dinh, Tuan
Author_Institution :
U.S. Army Res. Office, Durham, NC, USA
Volume :
10
Issue :
3
fYear :
2010
fDate :
3/1/2010 12:00:00 AM
Firstpage :
608
Lastpage :
616
Abstract :
This paper describes methodologies for developing efficient surface-enhanced Raman scattering (SERS) substrates such as annealing thin gold films for developing gold nanoislands, fabrication of nanopillars arrays and roughened films by employing focused ion beam (FIB) milling of gold films, as well as overcoating deep-UV-fabricated silicon nanowires with a layer of gold film. Excitation of surface plasmons in these gold nanostructures leads to substantial enhancement in the Raman scattering signal obtained from molecules lying in the vicinity of the nanostructure surface. In this paper, we perform comparative studies of SERS signals from molecules such as p-mercaptobenzoic acid and cresyl fast violet attached to or adsorbed on various gold SERS substrates. It was observed that gold-coated silicon nanowire substrates and annealed gold island substrates provided considerably higher SERS signals as compared to those from the FIB patterned substrates and planar gold films. The SERS substrates developed by the different processes were employed for detection of biological molecules such as dipicolinic acid, an excellent marker for spores of bacteria such as Anthrax.
Keywords :
Raman spectra; annealing; biomedical measurement; gold; molecular biophysics; substrates; surface plasmons; Anthrax; FIB patterned substrates; SERS substrates; biological molecule detection; chemical molecule detection; deep-UV-fabricated silicon nanowires; dipicolinic acid; focused ion beam milling; gold nanoislands; nanopillars arrays; p-mercaptobenzoic acid; surface-enhanced Raman scattering; thin gold films annealing; Annealing; Chemicals; Gold; Nanobioscience; Raman scattering; Rough surfaces; Semiconductor films; Silicon; Substrates; Surface roughness; Annealing; focused ion beam; nanoislands; nanopillars; nanowires; surface plasmons; surface-enhanced Raman scattering (SERS);
fLanguage :
English
Journal_Title :
Sensors Journal, IEEE
Publisher :
ieee
ISSN :
1530-437X
Type :
jour
DOI :
10.1109/JSEN.2009.2038634
Filename :
5419269
Link To Document :
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