Title :
Electrophysiologic models of heart cells and cell networks
Author :
Thakor, Nitish V. ; Ferrero, Jose M., Jr. ; Salz, J. ; Gramatikov, Boris L. ; Ferrero, Jose M., Sr.
Author_Institution :
Dept. of Biomed. Eng., Johns Hopkins Univ., Baltimore, MD, USA
Abstract :
This article summarizes the basic principles of action potential models, reviews the development of cellular models of normal and diseased cells, and discusses some important contributions of computer simulations to the understanding of arrhythmia generation in heart-cell networks. The article should enable a better understanding of arrhythmias and heart disease
Keywords :
bioelectric potentials; cardiology; cellular biophysics; digital simulation; physiological models; action potential models; arrhythmia generation; cell networks; computer simulations; diseased cells; electrophysiologic models; heart cells; heart disease; normal cells; Biomembranes; Computational modeling; Computer simulation; Electrophysiology; Heart; Instruments; Kinetic theory; Mathematical model; Nerve fibers; Voltage;
Journal_Title :
Engineering in Medicine and Biology Magazine, IEEE
