The intravenous route to blood glucose control

Author

Parker, Robert S. ; Doyle, Francis J., III ; Peppas, Nicholas A.

Author_Institution

Dept. of Chem. Eng., Delaware Univ., Newark, DE, USA

Volume

20

Issue

1

fYear

2001

Firstpage

65

Lastpage

73

Abstract

This article discusses closed-loop blood glucose regulation algorithms that use the intravenous route for insulin delivery to insulin-dependent diabetic patients. Classical control methods and advanced algorithms using implicit knowledge or explicit models (empirical, fundamental, or “gray-box”) of the diabetic patient are examined. Current research on characterizing patient variability is presented, in the context of a model predictive controller able to adjust to changes in patient glucose and insulin sensitivity

Keywords

biochemistry; biocontrol; blood; chemical variables control; diseases; patient monitoring; patient treatment; reviews; advanced algorithms; classical control methods; control algorithms; explicit models; implicit knowledge; insulin sensitivity; intravenous route; model predictive controller; noninvasive monitoring; patient glucose changes; patient variability; type I diabetic patients; Biomedical engineering; Biomedical monitoring; Blood; Catheters; Diabetes; Diseases; Insulin; Pancreas; Patient monitoring; Sugar;

fLanguage

English

Journal_Title

Engineering in Medicine and Biology Magazine, IEEE

Publisher

ieee

ISSN

0739-5175

Type

jour

DOI

10.1109/51.897829

Filename

897829