Title :
Fluorescence Lifetime Spectroscopy and Imaging in Neurosurgery
Author :
Marcu, Laura ; Hartl, Brad A.
Author_Institution :
Univ. of California, Davis, CA, USA
Abstract :
Clinical outcome of patients diagnosed with primary brain tumor has been correlated with the extent of surgical resection. In treating this disease, the neurosurgeon must balance between an aggressive, radical resection and minimizing the loss of healthy, functionally significant brain tissue. Numerous intraoperative methodologies and technological approaches have been explored as a means to improve the accuracy of surgical resection. This paper presents an overview of current conventional techniques and new emerging technologies with potential to impact the area of image-guided surgery of brain tumors. Emphasis is placed on techniques based on endogenous fluorescence lifetime contrast and their potential for intraoperative diagnosis of brain tumors.
Keywords :
biomedical optical imaging; brain; diseases; fluorescence spectroscopy; neurophysiology; patient diagnosis; surgery; tumours; brain tissue; brain tumors; disease; fluorescence lifetime spectroscopy; image-guided surgery; neurosurgeon; neurosurgery; patient diagnosis; radical resection; surgical resection; Fluorescence; Image resolution; Instruments; Magnetic resonance imaging; Surgery; Tumors; Autofluorescence; brain tumor; fluorescence; glioma; imaging; neurosurgery; spectroscopy; surgery;
Journal_Title :
Selected Topics in Quantum Electronics, IEEE Journal of
DOI :
10.1109/JSTQE.2012.2185823