Title :
Projection X-Space Magnetic Particle Imaging
Author :
Goodwill, Patrick W. ; Konkle, Justin J. ; Zheng, Bo ; Saritas, Emine U. ; Conolly, Steven M.
Author_Institution :
Dept. of Bioeng., Univ. of California, Berkeley, CA, USA
fDate :
5/1/2012 12:00:00 AM
Abstract :
Projection magnetic particle imaging (MPI) can improve imaging speed by over 100-fold over traditional 3-D MPI. In this work, we derive the 2-D x-space signal equation, 2-D image equation, and introduce the concept of signal fading and resolution loss for a projection MPI imager. We then describe the design and construction of an x-space projection MPI scanner with a field gradient of 2.35 T/m across a 10 cm magnet free bore. The system has an expected resolution of 3.5 × 8.0 mm using Resovist tracer, and an experimental resolution of 3.8 × 8.4 mm resolution. The system images 2.5 cm × 5.0 cm partial field-of views (FOVs) at 10 frames/s, and acquires a full field-of-view of 10 cm × 5.0 cm in 4 s. We conclude by imaging a resolution phantom, a complex “Cal” phantom, mice injected with Resovist tracer, and experimentally confirm the theoretically predicted x-space spatial resolution.
Keywords :
biomedical MRI; diagnostic radiography; phantoms; 2D X-space signal equation; 2D image equation; complex cal phantom; imaging resolution phantom; magnet free bore; mice injection; projection MPI imaging; projection X-space magnetic particle imaging; resovist tracer; signal fading; theoretically predicted X-space spatial resolution; traditional 3D MPI; Fading; Image reconstruction; Image resolution; Magnetic noise; Magnetic resonance imaging; Saturation magnetization; Angiography biomedical imaging; magnetic particle imaging (MPI); magnetic particles; Angiography; Animals; Brain Chemistry; Computer Simulation; Contrast Media; Dextrans; Liver; Magnetite Nanoparticles; Mice; Myocardium; Phantoms, Imaging; Tissue Distribution;
Journal_Title :
Medical Imaging, IEEE Transactions on
DOI :
10.1109/TMI.2012.2185247
