Title :
A pressure controller for estimating parameters for a nonlinear CSF model
Author :
Charlton, J.D. ; Guess, H.A. ; Mann, J.D. ; Nagle, H.T. ; Johnson, R.N.
Author_Institution :
Biomed. Eng. & Math. Curriculum, North Carolina Univ., Chapel Hill, NC, USA
Abstract :
Pressure feedback control of cerebrospinal fluid (CSF) infusion rate was used to estimate the parameters of a nonlinear model of the CSF system. The steady-state pressure and infusion rate were used to estimate the parameters of CSF formation and CSF absorption using the nonlinear least-squares method. The CSF compliance was then estimated using the transient portion of the pressure/infusion rate responses.
Keywords :
controllers; parameter estimation; physiological models; pressure control; nonlinear cerebrospinal fluid infusion rate; nonlinear least-squares method; pressure controller; pressure feedback control; Absorption; Biomedical engineering; Circuits; Mathematics; Nervous system; Parameter estimation; Piecewise linear techniques; Pressure control; Pulse modulation; Testing; Animals; Cerebrospinal Fluid; Equipment Design; Humans; Infusions, Parenteral; Intracranial Pressure; Models, Biological; Rats;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
