Title :
Analytical solution to the three-compartment pharmacokinetic model
Author_Institution :
Dept. of Anesthesiology, Duke Univ. Med. Center, Durham, NC, USA
Abstract :
Simulations of pharmacokinetic models in software usually rely on discrete approximation of the continuous differential equations describing the system, but this need not be the case. Here, the analytical equations describing the temporal behavior of the three-compartment open pharmacokinetic model are derived, and an algorithm for their use in pharmacokinetic simulations is given.
Keywords :
physiological models; 3-compartment pharmacokinetic model; algorithm; analytical equations; pharmacokinetic simulations; Algorithm design and analysis; Analytical models; Computational modeling; Computer simulation; Differential equations; Drugs; Jacobian matrices; Kinetic theory; Laplace equations; Time domain analysis; Algorithms; Computer Simulation; Models, Biological; Pharmacokinetics;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
