DocumentCode
1441247
Title
Analytical solution to the three-compartment pharmacokinetic model
Author
Jacobs, J.R.
Author_Institution
Dept. of Anesthesiology, Duke Univ. Med. Center, Durham, NC, USA
Volume
35
Issue
9
fYear
1988
Firstpage
763
Lastpage
765
Abstract
Simulations of pharmacokinetic models in software usually rely on discrete approximation of the continuous differential equations describing the system, but this need not be the case. Here, the analytical equations describing the temporal behavior of the three-compartment open pharmacokinetic model are derived, and an algorithm for their use in pharmacokinetic simulations is given.
Keywords
physiological models; 3-compartment pharmacokinetic model; algorithm; analytical equations; pharmacokinetic simulations; Algorithm design and analysis; Analytical models; Computational modeling; Computer simulation; Differential equations; Drugs; Jacobian matrices; Kinetic theory; Laplace equations; Time domain analysis; Algorithms; Computer Simulation; Models, Biological; Pharmacokinetics;
fLanguage
English
Journal_Title
Biomedical Engineering, IEEE Transactions on
Publisher
ieee
ISSN
0018-9294
Type
jour
DOI
10.1109/10.7279
Filename
7279
Link To Document