DocumentCode :
1444444
Title :
Fast Semi-Analytical Model-Based Acoustic Inversion for Quantitative Optoacoustic Tomography
Author :
Rosenthal, Amir ; Razansky, Daniel ; Ntziachristos, Vasilis
Author_Institution :
Inst. for Biol. & Med. Imaging, Tech. Univ. Munchen, Neuherberg, Germany
Volume :
29
Issue :
6
fYear :
2010
fDate :
6/1/2010 12:00:00 AM
Firstpage :
1275
Lastpage :
1285
Abstract :
We present a fast model-based inversion algorithm for quantitative 2-D and 3-D optoacoustic tomography. The algorithm is based on an accurate and efficient forward model, which eliminates the need for regularization in the inversion process while providing modeling flexibility essential for quantitative image formation. The resulting image-reconstruction method eliminates stability problems encountered in previously published model-based techniques and, thus, enables performing image reconstruction in real time. Our model-based framework offers a generalization of the forward solution to more comprehensive optoacoustic propagation models, such as including detector frequency response, without changing the inversion procedure. The reconstruction speed and other algorithmic performances are demonstrated using numerical simulation studies and experimentally on tissue-mimicking optically heterogeneous phantoms and small animals. In the experimental examples, the model-based reconstructions manifested correctly the effect of light attenuation through the objects and did not suffer from the artifacts which usually afflict the commonly used filtered backprojection algorithms, such as negative absorption values.
Keywords :
acoustic tomography; image reconstruction; medical image processing; optical tomography; phantoms; photoacoustic spectroscopy; 2D optoacoustic tomography; 3D optoacoustic tomography; algorithmic performances; comprehensive optoacoustic propagation models; detector frequency response; filtered backprojection algorithms; forward model; forward solution; image formation; image-reconstruction method; light attenuation; negative absorption values; numerical simulation; reconstruction speed; semianalytical model-based acoustic inversion; small animals; tissue-mimicking optically heterogeneous phantoms; Detectors; Frequency response; Image reconstruction; Imaging phantoms; Numerical simulation; Optical attenuators; Optical filters; Optical propagation; Stability; Tomography; Imaging; inverse problems; optoacoustics; photoacoustics; tomography; Algorithms; Computer Simulation; Elasticity Imaging Techniques; Image Enhancement; Image Interpretation, Computer-Assisted; Imaging, Three-Dimensional; Models, Biological; Reproducibility of Results; Sensitivity and Specificity;
fLanguage :
English
Journal_Title :
Medical Imaging, IEEE Transactions on
Publisher :
ieee
ISSN :
0278-0062
Type :
jour
DOI :
10.1109/TMI.2010.2044584
Filename :
5433071
Link To Document :
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