Title :
Estimation of cardiac function from computer analysis of the arterial pressure waveform
Author :
Guarini, Marcello ; Urzúa, Jorge ; Cipriano, Aldo ; González, Waldo
Author_Institution :
Dept. of Electr. Eng. & Anesthesiology, Catholic Univ. of Chile, Santiago, Chile
Abstract :
This paper presents a method for estimating parameters of a cardiovascular model, including the left-ventricular function, using the sequential quadratic programming (SQP) and the least minimum square (LMS) algorithms. In a first stage, a radial arterial-pressure waveform with corresponding cardiac output are used to automatically seek the set of parameters of the diastolic model. Computer simulation of the model using these parameters generate a pressure waveform and a cardiac output very close to those used for the estimation. In a second stage, the estimated arterial load parameters are used to select the best left-ventricular model function, from four different possibilities, and to estimate its optimum parameter values. The method has been tested numerically and applied to real cases, using data obtained from cardiovascular patients. It has also been subjected to preliminary validation using data obtained from laboratory dogs, in which cardiovascular function was artificially altered.
Keywords :
blood pressure measurement; cardiology; digital simulation; medical signal processing; physiological models; quadratic programming; arterial pressure waveform computer analysis; cardiac function estimation; cardiac output; cardiovascular modeling; computer simulation; diastolic model; least minimum square algorithm; left-ventricular function; radial arterial-pressure waveform; sequential quadratic programming; ventricular function; Blood pressure; Cardiology; Computational modeling; Computer simulation; Humans; Least squares approximation; Load modeling; Parameter estimation; Quadratic programming; Testing; Algorithms; Animals; Blood Flow Velocity; Blood Pressure; Computer Simulation; Dogs; Humans; Least-Squares Analysis; Models, Cardiovascular; Ventricular Function, Left;
Journal_Title :
Biomedical Engineering, IEEE Transactions on