A Skin-Contact-Actuated Micropump for Transdermal Drug Delivery

Author

Mousoulis, Charilaos ; Ochoa, Manuel ; Papageorgiou, Demetrios ; Ziaie, Babak

Author_Institution

Sch. of Electr. & Comput. Eng., Purdue Univ., West Lafayette, IN, USA

Volume

58

Issue

5

fYear

2011

fDate

5/1/2011 12:00:00 AM

Firstpage

1492

Lastpage

1498

Abstract

In this paper, a skin-contact-actuated dispenser/micropump for transdermal drug delivery applications is presented. The micropump consists of stacked polydimethylsiloxane layers mounted on a silicon substrate and operates based on the evaporation and condensation of a low-boiling-point liquid. Therefore, there is no need for a heater and a power source, since only the thermal energy provided by skin contact is required for the actuation. A prototype device with overall dimensions of 14 mm × 14 mm × 8 mm is fabricated and characterized. For a perfluoro compound working fluid (3M FC-3284), a flow rate of 28.8 μ L/min and a maximum back pressure of 28.9 kPa is measured.

Keywords

bioMEMS; boiling point; cellular biophysics; drug delivery systems; micropumps; polymers; skin; Si; condensation; evaporation; low-boiling-point liquid; perfluoro compound working fluid; power source; prototype device; silicon substrate; skin-contact-actuated dispenser-micropump; stacked polydimethylsiloxane layers; thermal energy; transdermal drug delivery; Biomembranes; Drugs; Fluids; Micropumps; Silicon; Skin; Substrates; Microfluidics; micropump; phase-change liquid; polydimethylsiloxane (PDMS); transdermal drug delivery; Administration, Cutaneous; Animals; Chickens; Dimethylpolysiloxanes; Equipment Design; Humans; Infusion Pumps; Microfluidics; Nylons; Skin Physiological Phenomena; Temperature;

fLanguage

English

Journal_Title

Biomedical Engineering, IEEE Transactions on

Publisher

ieee

ISSN

0018-9294

Type

jour

DOI

10.1109/TBME.2011.2113347

Filename

5711653