Title :
Intravascular Photoacoustic Imaging
Author :
Wang, Bo ; Su, Jimmy L. ; Karpiouk, Andrei B. ; Sokolov, Konstantin V. ; Smalling, Richard W. ; Emelianov, Stanislav Y.
Author_Institution :
Dept. of Biomed. Eng., Univ. of Texas at Austin, Austin, TX, USA
Abstract :
Intravascular photoacoustic (IVPA) imaging is a catheter-based, minimally invasive, imaging modality capable of providing high-resolution optical absorption map of the arterial wall. Integrated with intravascular ultrasound (IVUS) imaging, combined IVPA and IVUS imaging can be used to detect and characterize atherosclerotic plaques building up in the inner lining of an artery. In this paper, we present and discuss various representative applications of combined IVPA/IVUS imaging of atherosclerosis, including assessment of the composition of atherosclerotic plaques, imaging of macrophages within the plaques, and molecular imaging of biomarkers associated with formation and development of plaques. In addition, imaging of coronary artery stents using IVPA and IVUS imaging is demonstrated. Furthermore, the design of an integrated IVUS/IVPA imaging catheter needed for in vivo clinical applications is discussed.
Keywords :
bio-optics; bioacoustics; biomedical ultrasonics; blood vessels; catheters; cellular biophysics; diseases; photoacoustic effect; stents; ultrasonic imaging; IVPA imaging; IVUS imaging; atherosclerosis; atherosclerotic plaques; biomarkers; catheter; coronary artery stents; high-resolution optical absorption map; intravascular photoacoustic imaging; intravascular ultrasound imaging; macrophages; Atherosclerosis; contrast agent; imaging catheter; intravascular photoacoustic (IVPA) imaging; intravascular ultrasound (IVUS) imaging; molecular imaging; stent; vulnerable plaque;
Journal_Title :
Selected Topics in Quantum Electronics, IEEE Journal of
DOI :
10.1109/JSTQE.2009.2037023
