Synthesis of Hybrid Gold/Iron Oxide Nanoparticles in Block Copolymer Micelles for Imaging, Drug Delivery, and Magnetic Hyperthermia

Author

Kim, Dong-Hyun ; Rozhkova, Elena A. ; Rajh, Tijana ; Bader, Samuel D. ; Novosad, Valentyn

Author_Institution

Mater. Sci. Div., Argonne Nat. Lab., Argonne, IL, USA

Volume

45

Issue

10

fYear

2009

Firstpage

4821

Lastpage

4824

Abstract

In our study, hybrid gold/iron oxide loaded thermoresponsive micelles were synthesized for combined hyperthermia and chemotherapy, and optical imaging. Polymeric micelles made of amphiphilic block copolymer of poly(N-isopropylacrylamide-co-acrylamide)-block-poly(epsiv-caprolactone) were conjugated with gold/iron oxide particles which are self-assembled at the hydrophobic polymer core. Thermal sensitivity and magnetic and optical properties of the hybrid gold/iron oxide micelles were investigated for the combined therapy and optical imaging.

Keywords

biomedical materials; biomedical optical imaging; colloids; drug delivery systems; gold; hydrophobicity; hyperthermia; iron compounds; magnetic particles; magnetisation; nanobiotechnology; nanocomposites; nanoparticles; polymer blends; self-assembly; surface plasmon resonance; Au-FeO; SPR spectra; amphiphilic block copolymer; block copolymer micelles; chemotherapy; drug delivery; hybrid gold-iron oxide nanoparticles; hydrophobic polymer; magnetic hyperthermia; magnetic properties; nanocomposites; optical imaging; optical properties; poly(N-isopropylacrylamide-coacrylamide)-block-poly(epsiv-caprolactone); polymeric micelles; saturation magnetization; self-assembly; surface plasmon resonance spectra; thermal sensitivity; thermoresponsive micelles; Drug delivery; gold nanoparticles; hybrid nanoparticles; hyperthermia; magnetic nanoparticles;

fLanguage

English

Journal_Title

Magnetics, IEEE Transactions on

Publisher

ieee

ISSN

0018-9464

Type

jour

DOI

10.1109/TMAG.2009.2024000

Filename

5257027