Title :
Response to Letter Regarding Article: “Developing DCE-CT to Quantify Intra-Tumor Heterogeneity in Breast Tumors With Differing Angiogenic Phenotype”
Author :
Cao, Minsong ; Liang, Yun ; Stantz, Keith M.
Author_Institution :
Sch. of Health Sci., Purdue Univ., West Lafayette, IN, USA
fDate :
4/1/2010 12:00:00 AM
Abstract :
In this response letter, technical issues raised by the comments concerning determination of arterial input function, cardiac and respiratory related motion artifacts, contrast agent application, and compartmental model fitting in our work are addressed in detail, and a discussion on identifying causes of uncertainty in physiological measurement and how to minimize their contribution is presented.
Keywords :
computerised tomography; mammography; physiology; tumours; DCE-CT development; angiogenic phenotype; arterial input function; breast tumors; cardiac related motion artifacts; compartmental model fitting; contrast agent application; dynamic contrast enhanced computed tomography; intratumor heterogeneity; physiological measurement; respiratory related motion artifacts; Compartmental model; dynamic contrast enhanced computed tomography (DCE-CT); tumor heterogeneity;
Journal_Title :
Medical Imaging, IEEE Transactions on
DOI :
10.1109/TMI.2009.2039224
