Title :
Novel In Vitro and In Vivo Neural Interfaces: Normal and Accelerated Failure Assessment
Author :
Otto, Kevin J. ; Williams, Justin C.
Author_Institution :
Dept. of Biol. Sci., Purdue Univ., West Lafayette, IN, USA
Abstract :
The in vitro acute brain slice test bed offers the advantages of natural configurations and proportions of cells and tissues. As a function of time, electrode insertion activates signaling pathways in microglia, astrocytes, and neurons that result in biochemical changes that alter the biophysical characteristics of the tissue.Temperature- modulated acceleration, based onthe Arrhenius equation, is a common method to predict the lifetime of samples.
Keywords :
biomedical electrodes; brain-computer interfaces; failure analysis; life testing; neurophysiology; Arrhenius equation; astrocytes; biochemical changes; brain slice test bed; electrode insertion; failure assessment; microglia; neural interfaces; neurons; signaling pathways; temperature- modulated acceleration; Biological tissues; Central nervous system; Implantable biomedical devices; Implants; Injuries; Neuroscience; Pathology; Animals; Bioengineering; Electrodes, Implanted; Humans; Models, Neurological; Nerve Net; Signal Transduction; User-Computer Interface;
Journal_Title :
Pulse, IEEE
DOI :
10.1109/MPUL.2011.2175631
