On-Chip Stochastic Resonance of Ion Channel Systems With Variable Internal Noise

Author

Stava, Eric ; Choi, Siyoung ; Kim, Hyun-Seok ; Blick, Robert H.

Author_Institution

Inst. fur Angewandte Phys. und Zentrum fur Mikrostrukturforschung, Univ. Hamburg, Hamburg, Germany

Volume

11

Issue

2

fYear

2012

fDate

6/1/2012 12:00:00 AM

Firstpage

169

Lastpage

175

Abstract

We induced stochastic resonance in planar lipid bilayer systems with alamethicin ion channels, and varied alamethicin concentration, membrane area, and applied voltage. We found that membrane-induced microphonic noise significantly affects the signature of stochastic resonance, and that this noise can be used to optimize ion channel-based biosensors.

Keywords

bioelectric phenomena; biomembrane transport; lipid bilayers; noise; organic compounds; stochastic processes; alamethicin concentration; alamethicin ion channels; biosensors; microphonic noise; on-chip stochastic resonance; planar lipid bilayer; variable internal noise; Biomembranes; Electric potential; Lipidomics; Noise level; Signal to noise ratio; Strontium; Biomembranes; biosensors; ion channels; microphonic noise; stochastic resonance; Alamethicin; Biosensing Techniques; Electric Impedance; Ion Channels; Lab-On-A-Chip Devices; Lipid Bilayers; Models, Theoretical; Signal-To-Noise Ratio; Stochastic Processes;

fLanguage

English

Journal_Title

NanoBioscience, IEEE Transactions on

Publisher

ieee

ISSN

1536-1241

Type

jour

DOI

10.1109/TNB.2012.2188539

Filename

6166894