Title :
On-Chip Stochastic Resonance of Ion Channel Systems With Variable Internal Noise
Author :
Stava, Eric ; Choi, Siyoung ; Kim, Hyun-Seok ; Blick, Robert H.
Author_Institution :
Inst. fur Angewandte Phys. und Zentrum fur Mikrostrukturforschung, Univ. Hamburg, Hamburg, Germany
fDate :
6/1/2012 12:00:00 AM
Abstract :
We induced stochastic resonance in planar lipid bilayer systems with alamethicin ion channels, and varied alamethicin concentration, membrane area, and applied voltage. We found that membrane-induced microphonic noise significantly affects the signature of stochastic resonance, and that this noise can be used to optimize ion channel-based biosensors.
Keywords :
bioelectric phenomena; biomembrane transport; lipid bilayers; noise; organic compounds; stochastic processes; alamethicin concentration; alamethicin ion channels; biosensors; microphonic noise; on-chip stochastic resonance; planar lipid bilayer; variable internal noise; Biomembranes; Electric potential; Lipidomics; Noise level; Signal to noise ratio; Strontium; Biomembranes; biosensors; ion channels; microphonic noise; stochastic resonance; Alamethicin; Biosensing Techniques; Electric Impedance; Ion Channels; Lab-On-A-Chip Devices; Lipid Bilayers; Models, Theoretical; Signal-To-Noise Ratio; Stochastic Processes;
Journal_Title :
NanoBioscience, IEEE Transactions on
DOI :
10.1109/TNB.2012.2188539
