Title :
Modeling the dynamics of HIV-1 and CD4 and CD8 lymphocytes
Author :
Menezes Campello de Souza, F.
Author_Institution :
Univ. Fed. de Pernambuco, Recife, Brazil
Abstract :
The nonlinear dynamic model presented in this article includes most aspects known thus far regarding the dynamics of HIV-1 in the human body. It permits an analytical study of the dynamics of the disease (AIDS). The parameters used in the model can be estimated from data obtained in sequential measures taken from patients without interrupting any treatment. The model can be used to determine the state of health of an individual, verify the effects of drugs, and make prognoses concerning the evolution of the patient, including correlations with clinical manifestations.
Keywords :
blood; cellular biophysics; diseases; physiological models; AIDS; CD4 lymphocytes; CD8 lymphocytes; HIV-1; acquired immune deficiency syndrome; analytical study; clinical manifestations; disease dynamics modeling; drugs; human body; individual health state; nonlinear dynamic model; patient; white blood cells; Acquired immune deficiency syndrome; Biomedical engineering; Differential equations; Diseases; Drugs; Immune system; Medical treatment; Motion control; Nonlinear control systems; Nonlinear dynamical systems; Acquired Immunodeficiency Syndrome; Antiviral Agents; CD4-CD8 Ratio; HIV-1; Humans; Models, Immunological; Nonlinear Dynamics; Viral Load;
Journal_Title :
Engineering in Medicine and Biology Magazine, IEEE
