A high-sensitivity micromachined biosensor

Author

Baselt, David R. ; Lee, Gil U ; Hansen, Karolyn M. ; Chrisey, Linda A. ; Colton, Richard J.

Author_Institution

Naval Res. Lab., Washington, DC, USA

Volume

85

Issue

4

fYear

1997

fDate

4/1/1997 12:00:00 AM

Firstpage

672

Lastpage

680

Abstract

The Force Amplified Biological Sensor (FABS) is a desktop or portable instrument currently under development at the Naval Research Laboratory. FABS will use a rapid, automated immunoassay to detect analytes such as proteins, viruses, and bacteria. The assay uses forces produced by micron-sized magnetic particles to pull on antibody-antigen bonds. Microfabricated piezoresistive cantilevers measure the resulting piconewton-level forces with sufficient sensitivity to detect single antibody-antigen bonds. These forces also serve to characterize the bonds, allowing FABS to distinguish specific antibody-antigen bonds from nonspecific interactions

Keywords

biosensors; magnetic particles; magnetic sensors; micromachining; microsensors; piezoresistive devices; analyte detection; antibody-antigen bonds; automated immunoassay; bacteria; desktop instrument; force amplified biological sensor; magnetic particles; micromachined biosensor; nonspecific interactions; piezoresistive cantilever; portable instrument; proteins; viruses; Biosensors; Force sensors; Immune system; Instruments; Laboratories; Magnetic analysis; Magnetic particles; Microorganisms; Proteins; Viruses (medical);

fLanguage

English

Journal_Title

Proceedings of the IEEE

Publisher

ieee

ISSN

0018-9219

Type

jour

DOI

10.1109/5.573755

Filename

573755