DocumentCode
1478361
Title
Maximum a Posteriori Estimation of Linear Shape Variation With Application to Vertebra and Cartilage Modeling
Author
Crimi, Alessandro ; Lillholm, Martin ; Nielsen, Mads ; Ghosh, Anarta ; De Bruijne, Marleen ; Dam, Erik B. ; Sporring, Jon
Author_Institution
Dept. of Comput. Sci. (DIKU), Univ. of Copenhagen, Copenhagen, Denmark
Volume
30
Issue
8
fYear
2011
Firstpage
1514
Lastpage
1526
Abstract
The estimation of covariance matrices is a crucial step in several statistical tasks. Especially when using few samples of a high dimensional representation of shapes, the standard maximum likelihood estimation (ML) of the covariance matrix can be far from the truth, is often rank deficient, and may lead to unreliable results. In this paper, we discuss regularization by prior knowledge using maximum a posteriori (MAP) estimates. We compare ML to MAP using a number of priors and to Tikhonov regularization. We evaluate the covariance estimates on both synthetic and real data, and we analyze the estimates´ influence on a missing-data reconstruction task, where high resolution vertebra and cartilage models are reconstructed from incomplete and lower dimensional representations. Our results demonstrate that our methods outperform the traditional ML method and Tikhonov regularization.
Keywords
biological tissues; covariance matrices; maximum likelihood estimation; MAP estimates; Tikhonov regularization; cartilage modeling; covariance matrices; linear shape variation; maximum a posteriori estimation; maximum likelihood estimation; vertebra modeling; Biomedical imaging; Covariance matrix; Eigenvalues and eigenfunctions; Maximum likelihood estimation; Shape; Symmetric matrices; Bayesian; Tikhonov regularization; cartilage; covariance estimation; incomplete data; maximum a posteriori (MAP); principal component analysis (PCA); reconstruction; regularization; shape model; vertebra; Adult; Aged; Algorithms; Bayes Theorem; Cartilage, Articular; Computer Simulation; Female; Humans; Image Processing, Computer-Assisted; Knee Joint; Lumbar Vertebrae; Magnetic Resonance Imaging; Male; Middle Aged; Models, Anatomic; Principal Component Analysis; Radiography;
fLanguage
English
Journal_Title
Medical Imaging, IEEE Transactions on
Publisher
ieee
ISSN
0278-0062
Type
jour
DOI
10.1109/TMI.2011.2131150
Filename
5737789
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