Title :
Modeling Biopotential Signals and Current Densities of Multiple Breast Cancerous Cells
Author :
Hassan, Ahmed M. ; El-Shenawee, Magda
Author_Institution :
Dept. of Electr. Eng., Univ. of Arkansas, Fayetteville, AR, USA
Abstract :
This study presents a model to simulate the electrophysiological activities of multiple Michigan Cancer Foundation-7 (MCF-7) cells, the most studied breast cancer cell line. The intercellular spacing of MCF-7 cells is estimated using the effective diffusion coefficient. Nonuniform finite-difference discretization is implemented to accommodate for the contrast in size between the intercellular spacing and the cell dimension. The model computes the amplitude and the spatiotemporal patterns of biopotentials and electric current densities at different cell division stages. The results show that the biopotentials increase proportionally to the number of cells, especially when all cells are in the hyperpolarization stage. Also, the results show significant electric current density in the intercellular gap between the cells.
Keywords :
biodiffusion; bioelectric potentials; cancer; cellular biophysics; finite difference methods; MCF-7 cells; biopotential signals; biopotentials; cell dimension; cell division; effective diffusion coefficient; electric current density; electrophysiological activities; hyperpolarization; intercellular gap; intercellular spacing; multiple Michigan Cancer Foundation-7 cells; multiple breast cancerous cells; nonuniform finite-difference discretization; spatiotemporal patterns; Bioelectric phenomena; Michigan Cancer Foundation-7 (MCF-7) cells; biological cells; biophysics; cancer; Algorithms; Breast Neoplasms; Cell Line, Tumor; Cell Physiological Phenomena; Electrophysiological Processes; Female; Humans; Magnetic Resonance Imaging; Models, Biological; Ultrasonography, Mammary;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
DOI :
10.1109/TBME.2010.2049575
