Title :
Toward A Highly Specific DNA Biosensor: PNA-Modified Suspended-Core Photonic Crystal Fibers
Author :
Coscelli, Enrico ; Sozzi, Michele ; Poli, Federica ; Passaro, Davide ; Cucinotta, Annamaria ; Selleri, Stefano ; Corradini, Roberto ; Marchelli, Rosangela
Author_Institution :
Dept. of Inf. Eng., Univ. of Parma, Parma, Italy
Abstract :
The feasibility of a biosensor for DNA detection based on suspended-core photonic crystal fibers is investigated. The possibility of functionalization of the hole surface, which allows DNA strand binding, is demonstrated, along with the selective detection of DNA through hybridization of immobilized peptide nucleic acid probes with their full-complementary and mismatched DNA segments.
Keywords :
DNA; bio-optics; biosensors; molecular biophysics; DNA detection; DNA strand binding; PNA-modified suspended-core photonic crystal fiber; highly specific DNA biosensor; holey fiber; immobilized peptide nucleic acid probe; microstructured optical fiber; mismatched DNA segment; selective DNA detection; Biosensor; DNA; peptide nucleic acid (PNA); photonic crystal fiber (PCF);
Journal_Title :
Selected Topics in Quantum Electronics, IEEE Journal of
DOI :
10.1109/JSTQE.2009.2031923
