DocumentCode :
1493982
Title :
Toward A Highly Specific DNA Biosensor: PNA-Modified Suspended-Core Photonic Crystal Fibers
Author :
Coscelli, Enrico ; Sozzi, Michele ; Poli, Federica ; Passaro, Davide ; Cucinotta, Annamaria ; Selleri, Stefano ; Corradini, Roberto ; Marchelli, Rosangela
Author_Institution :
Dept. of Inf. Eng., Univ. of Parma, Parma, Italy
Volume :
16
Issue :
4
fYear :
2010
Firstpage :
967
Lastpage :
972
Abstract :
The feasibility of a biosensor for DNA detection based on suspended-core photonic crystal fibers is investigated. The possibility of functionalization of the hole surface, which allows DNA strand binding, is demonstrated, along with the selective detection of DNA through hybridization of immobilized peptide nucleic acid probes with their full-complementary and mismatched DNA segments.
Keywords :
DNA; bio-optics; biosensors; molecular biophysics; DNA detection; DNA strand binding; PNA-modified suspended-core photonic crystal fiber; highly specific DNA biosensor; holey fiber; immobilized peptide nucleic acid probe; microstructured optical fiber; mismatched DNA segment; selective DNA detection; Biosensor; DNA; peptide nucleic acid (PNA); photonic crystal fiber (PCF);
fLanguage :
English
Journal_Title :
Selected Topics in Quantum Electronics, IEEE Journal of
Publisher :
ieee
ISSN :
1077-260X
Type :
jour
DOI :
10.1109/JSTQE.2009.2031923
Filename :
5280348
Link To Document :
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