Stilbene and Its Derivatives for Multistate Spectral Sensing

Terahertz (THz) region in the vibrational spectra of a certain molecule reveals the intramolecular vibrations between weakly bonded or nonbonded groups. Additional information can be acquired by photoinduced transitions between metastable states of the target agent. Different isomers of stilbene and its derivatives can be utilized in order to obtain the spectral “THz fingerprint” using multistate spectral-sensing technology. Also, stilbene and its derivatives are able to form “capping” with DNA, thus making them a very important covalent linker with DNA terminus to increase the fidelity of DNA duplexes as oligonucleotide hybridization probes. We study photoinduced transitions of stilbene and its derivatives and the change of vibrational spectra as a result of these transitions. All derivatives have vibrational frequencies in the THz region with a large difference in frequencies between two isomers.