Title :
The computational challenge of linkage analysis: what causes diseases?
Author_Institution :
Whitehead Inst., MIT, Cambridge, MA, USA
Abstract :
Finding the genetic causes of disease is a challenging problem for biologists and mathematicians alike. This article describes the difficulties of the problem, two general algorithmic approaches to solving it, and areas of current research where the problem has not yet been adequately solved
Keywords :
biology computing; genetics; medical computing; algorithmic approaches; biology; disease; genetics; linkage analysis; mathematics; Bioinformatics; Biological cells; Biology computing; Couplings; DNA; Diseases; Genetic mutations; Genomics; Information analysis; Testing;
Journal_Title :
Computing in Science & Engineering
DOI :
10.1109/5992.764212
